Reaktion #41156

Reaktionsgleichung

Cyclohexylhydrazine hydrochloride

ethyl (ethoxymethylene)-cyanoacetate

sodium acetate

→

5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

Ausbeute 92.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthen cooled to room temperature
2. 2
   Einengenconcentrated
3. 3
   SonstigeThe residue was partitioned between methylene chloride and water
4. 4
   ExtraktionThe separated aqueous phase was extracted with a second portion of methylene chloride
5. 5
   WaschenThe organic phases were successively washed with water and brine
6. 6
   Trocknendried over sodium sulfate
7. 7
   Einengenconcentrated in vacuo
8. 8
   SonstigeThe residue was purified by flash chromatography
9. 9
   Wascheneluting with a gradient of 25-70% ethyl acetate/hexanes

Vorschrift

Cyclohexylhydrazine hydrochloride (3.057 g, 20.29 mmol, CAS #24214-73-1, purchased from Aldrich) was combined with ethyl (ethoxymethylene)-cyanoacetate (3.390 g, 20.04 mmol) and anhydrous sodium acetate (2.080 g, 25.36 mmol) in 30 mL ethanol. The mixture was heated at 70° C. for 16 hours then cooled to room temperature and concentrated. The residue was partitioned between methylene chloride and water. The separated aqueous phase was extracted with a second portion of methylene chloride. The organic phases were successively washed with water and brine and then combined, dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography eluting with a gradient of 25-70% ethyl acetate/hexanes to give 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (4.42 g, 92%). Mass spectrum: m/z: 238.1 (M+H).

Quelle