Reaktion #41119

Reaktionsgleichung

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

DL-3-pyrrolidinol

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5-(3-Hydroxy-pyrrolidin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturHeating
2. 2
   Sonstigeunder microwave irradiation
3. 3
   Sonstigeprovided
4. 4
   Sonstigeafter purification by reverse phase HPLC, 5-(3-hydroxy-pyrrolidin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (68 mg, 66%) as an off-white powder

Vorschrift

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and DL-3-pyrrolidinol (0.25 mL; 3.0 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-(3-hydroxy-pyrrolidin-1-yl)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (68 mg, 66%) as an off-white powder. ES-HRMS m/e calcd for C19H29N4O2 (M+H+) 345.2285, found 345.2281.

Quelle