Reaktion #411181

Reaktionsgleichung

Thionyl chloride

4-morpholinepropane sulfonic acid

→

title compound

3-Morpholin-4-yl-propane-1-sulfonyl chloride hydrochloride

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturat reflux under nitrogen for 5 h
3. 3
   SonstigeThe thionyl chloride was removed in vacuo
4. 4
   Sonstigethe residue triturated with acetonitrile
5. 5
   Filtrationfiltered
6. 6
   Sonstigeto give a white solid
7. 7
   SonstigeThis was dried at 80° C. in vacuo

Vorschrift

Thionyl chloride (10 ml) was added to 4-morpholinepropane sulfonic acid (4.4 g) followed by dimethylformamide (0.2 ml). The mixture was heated at reflux under nitrogen for 5 h. The thionyl chloride was removed in vacuo and the residue triturated with acetonitrile and filtered to give a white solid. This was dried at 80° C. in vacuo to give the title compound as a white solid (2.7 g). Found: C,31.9; H,5.9; N,5.1. C7H14CINO3S.HCl requires C,31.8; H,5.7; N,5.3%.

Quelle