Reaktion #41105

Reaktionsgleichung

5-amino-1-tert-butyl-1H-pyrazole-4-carboxylic acid ethyl ester

t-butyl nitrite

HCl

→

1-tert-butyl-5-chloro-1H-pyrazole-4-carboxylic acid ethyl ester

Ausbeute 39.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 65° C. for 1 h
2. 2
   Extraktionextracted with dichloromethane
3. 3
   ExtraktionThe aqueous phase was extracted three times with dichloromethane
4. 4
   EinengenAfter the combined organic phases were concentrated in vacuo
5. 5
   Sonstigethe crude residue was purified by flash chromatography
6. 6
   Wascheneluting with a gradient of 0-20% ethyl acetate/hexanes

Vorschrift

To a mixture of t-butyl nitrite (7.2 mL, 60.5 mmol), cuprous chloride (4.8 g, 48.5 mmol), and anhydrous acetonitrile (120 mL) was added 5-amino-1-tert-butyl-1H-pyrazole-4-carboxylic acid ethyl ester (8.4 g, 39.8 mmol) in portions over 30 minutes at 0° C. The reaction mixture was stirred at room temperature for 1 h, then at 65° C. for 1 h. The mixture was then poured into 6N HCl (120 mL) and extracted with dichloromethane. The aqueous phase was extracted three times with dichloromethane. After the combined organic phases were concentrated in vacuo, the crude residue was purified by flash chromatography eluting with a gradient of 0-20% ethyl acetate/hexanes, then 20% ethyl acetate/hexanes to give 1-tert-butyl-5-chloro-1H-pyrazole-4-carboxylic acid ethyl ester (5.5 g, 39%).

Quelle