Reaktion #411039

Reaktionsgleichung

3-ethylxanthine

dimethylformamide

potassium carbonate

benzyl chloride

→

7-Benzyl-3-ethylxanthine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGIt was then stirred at 100° C. for 2 hours
2. 2
   Filtrationthe precipitated product was filtered on a suction
3. 3
   Filtrationfilter
4. 4
   Waschenwashed with water until salt-free and
5. 5
   Sonstigedried in a vacuum
6. 6
   Sonstigedrying oven at 100° C
7. 7
   SonstigeIf necessary, a further purification
8. 8
   Sonstigeby reprecipitating from 1 N sodium hydroxide solution

Vorschrift

180 g (1 mol) of 3-ethylxanthine were initially introduced into 1000 ml of dimethylformamide, the mixture was heated to 80° C. with stirring and, after the introduction of 88 g (0.64 mol) of potassium carbonate, treated dropwise with 133 g (1.05 mol) of benzyl chloride in the course of 1 hour. It was then stirred at 100° C. for 2 hours, treated with 1000 ml of water, and the precipitated product was filtered on a suction filter, washed with water until salt-free and dried in a vacuum drying oven at 100° C. If necessary, a further purification can be carried out by reprecipitating from 1 N sodium hydroxide solution using 4 N hydrochloric acid analogously to Example 1a).

Quelle