Reaktion #410601

Reaktionsgleichung

methyl 2-methoxy-5-aminobenzoate

di-2-pyridyl thionocarbonate

→

methyl 2-methoxy-5-thioisocyanatobenzoate

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextract five times with water
2. 2
   TrocknenDry the organic layer over Na2SO4
3. 3
   Filtrationfilter
4. 4
   Einengenconcentrate in vacuo

Vorschrift

According to the method of Tet. Let., 26, 1661 (1985), combine methyl 2-methoxy-5-aminobenzoate (0.5 g, 2.76 mmol) and di-2-pyridyl thionocarbonate (0.64 g, 2.76 mmol) in dichloromethane (10 mL). After 30 minutes, dilute the reaction mixture with dichloromethane and extract five times with water. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give methyl 2-methoxy-5-thioisocyanatobenzoate: Rf=0.51 (silica gel, dichloromethane).

Quelle