Reaktion #410572

Reaktionsgleichung

2-methoxy-5-methylthiobenzoic acid

methanol

thionyl chloride

→

methyl 2-methoxy-5-methylthiobenzoate

Lösungsmittel

hexane dichloromethane

hexane dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturCool in an ice bath
2. 2
   Sonstigeevaporate in vacuo
3. 3
   Sonstigeto give a residue

Vorschrift

Combine 2-methoxy-5-methylthiobenzoic acid (6.82 g, 34.4 mmol) and methanol (65 mL). Cool in an ice bath. Add slowly dropwise thionyl chloride (2.8 mL, 38 mmol). Warm to ambient temperature. After 18 hours, evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 25% hexane/dichloromethane to give methyl 2-methoxy-5-methylthiobenzoate, Rf=0.06 (silica gel, 65% hexane/dichloromethane).

Quelle