Reaktion #410330

Reaktionsgleichung

diethyl ether

4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide

magnesium dioxide

methanol

→

4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-formylphenyl)benzamide

Ausbeute 93.3%

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 3 hours
2. 2
   Filtrationthe solution was filtered through Celite
3. 3
   SonstigeThe filtrate was evaporated in vacuo
4. 4
   Sonstigeto give a crude oil

Vorschrift

A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide (225 mg) and magnesium dioxide (651 mg) in chloroform (10 ml) was refluxed for 3 hours and the solution was filtered through Celite. The filtrate was evaporated in vacuo to give a crude oil and the oil was subjected to silica gel column (1% methanol in chloroform). The product was solidified with diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-formylphenyl)benzamide (209 mg) as a white powder.

Quelle