Reaktion #41006

Reaktionsgleichung

Water

3-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride

K2CO3

3-Bromo-1,1dimethoxy-propane

→

yellow oil

Ausbeute 33.2%

3-[1-(3,3-Dimethoxy-propyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-pyridine-2-carbonitrile

Ausbeute 33.2%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinued for 48 hours
3. 3
   Extraktionthe product was extracted with ethyl acetate
4. 4
   TrocknenThe organic phase was dried (Na2SO4)
5. 5
   Sonstigeevaporated

Vorschrift

A mixture of 3-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride (Prep103, 500 mg, 2 mmol), and K2CO3 (413 mg, 3 mmol) in DMF (7 ml) was stirred for one hour at room temperature. 3-Bromo-1,1dimethoxy-propane (402 mg, 2.2 mmol) was added and stirring continued for 48 hours. Water was added and the product was extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 210 mg of a yellow oil (33% yield).

Quelle