Reaktion #410058

Reaktionsgleichung

3-benzyloxyphenol

ethyl (RS)-4-chloro-4-phenylbutanoate

potassium carbonate

potassium iodide

→

ethyl (RS)-4-(3-benzyloxyphenoxy)-4-phenylbutanoate

Ausbeute 17.1%

Lösungsmittel

methyl ethyl ketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   Temperaturat reflux for 40 hours
3. 3
   SonstigeThe mixture is evaporated to dryness
4. 4
   Sonstigethe residue is partitioned between ethyl acetate (200 mL) and water (200 mL)
5. 5
   TrocknenThe organic layer is dried over magnesium sulphate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo
8. 8
   WaschenFlash chromatography of the resulting oil, eluting with a mixture of ethyl acetate and cyclohexane (1:19 v/v)

Vorschrift

A mixture of 3-benzyloxyphenol (3 g), ethyl (RS)-4-chloro-4-phenylbutanoate (4.53 g), potassium carbonate (4.14 g), potassium iodide (100 mg) and methyl ethyl ketone (100 mL) is heated at reflux for 40 hours. The mixture is evaporated to dryness and the residue is partitioned between ethyl acetate (200 mL) and water (200 mL). The organic layer is dried over magnesium sulphate, filtered, and concentrated in vacuo. Flash chromatography of the resulting oil, eluting with a mixture of ethyl acetate and cyclohexane (1:19 v/v), gives ethyl (RS)-4-(3-benzyloxyphenoxy)-4-phenylbutanoate (1 g), in the form of a yellow oil.

Quelle