Reaktion #409960

ord-3d2d3ee5d08d4d1aaa6dcd0e8b4fb558

Reaktionsgleichung

C[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-(phenylacetyl)-L-alanine
COC(=O)[C@@H](N)Cc1ccccc1.Cl
L-phenylalanine methyl ester hydrochloride
→
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)Cc1ccccc1
title compound
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)Cc1ccccc1
N-[N-(Phenylacetyl)-L-alaninyl]-L-phenylalanine Methyl Ester

Edukte

C[C@H](NC(=O)Cc1ccccc1)C(=O)O
N-(phenylacetyl)-L-alanine
COC(=O)[C@@H](N)Cc1ccccc1.Cl
L-phenylalanine methyl ester hydrochloride
—
solid

Reagenzien

Keine

Lösungsmittel

—
EtOAc hexanes

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe product was not purified

Vorschrift

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-phenylalanine methyl ester hydrochloride (Aldrich), the title compound was prepared as a solid (mp=148-149.5° C.). The reaction was monitored by tlc (Rf=0.24 in 50% EtOAc/hexanes) and the product was not purified.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06211235B1uspto-grants-2001_04