Reaktion #40970

Reaktionsgleichung

Water

5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

K2CO3

3-bromo-1,1dimethoxy-propane

→

final compound

Ausbeute 53.0%

1-(3,3-Dimethoxy-propyl)-5-(2,4-dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

Ausbeute 53.0%

Lösungsmittel

DMF

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred at room temperature for 72 hours
2. 2
   Extraktionthe product extracted with ethyl acetate
3. 3
   TrocknenThe organic phase was dried (Na2SO4)
4. 4
   Sonstigeevaporated

Vorschrift

5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione (Prep62, 480 mg, 2.32 mmol) and K2CO3 (320 mg, 2.32 mmol) were suspended in dry DMF (6 ml) and stirred at room temperature for 1 h. A solution of 3-bromo-1,1dimethoxy-propane (467 mg, 2.55 mmol) in dry DMF (2 mL) was added dropwise and the mixture stirred at room temperature for 72 hours. Water (80 mL) was added and the product extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 377 mg of the final compound that was used without any other purification in the next step (53% yield).

Quelle