Reaktion #40966

Reaktionsgleichung

3-bromo-1,1dimethoxy-propane

5-(6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

K2CO3

Water

3-bromo-1,1dimethoxy-propane

→

final compound

Ausbeute 48.0%

1-(3,3-Dimethoxy-propyl)-5-(6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione

Ausbeute 48.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction at room temperature for 24 hours
2. 2
   Waschenthe mixture washed with diethyl ether
3. 3
   ExtraktionThe aqueous layer was then extracted with ethyl acetate
4. 4
   TrocknenThe organic phase was dried (Na2SO4)
5. 5
   Sonstigeevaporated

Vorschrift

5-(6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride (Prep57, 385 mg, 1.62 mmol), K2CO3 (224 mg, 1.62 mmol) and 3-bromo-1,1dimethoxy-propane (commercially available from Aldrich, 183 mg, 1.0 mmol) were suspended in dry DMF (8 mL). After stirring the reaction at room temperature for 24 hours, additional 3-bromo-1,1dimethoxy-propane (180 mg, 0.98 mmol) was added portionwise over a period of 96 h. Water was added and the mixture washed with diethyl ether. The aqueous layer was then extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 320 mg of the final compound that was used without further purification in the next step (48% yield).

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