Reaktion #40959

Reaktionsgleichung

2,4-Di-methoxy-pyrimidine-5-boronic acid

2-bromo-6-methylpyridine

Na2CO3

PPh3

→

title compound

Ausbeute 47.7%

2,4-Dimethoxy-5-(6-methyl-pyridin-2-yl)-pyrimidine

Ausbeute 47.7%

Lösungsmittel

n-PrOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 4 hours
2. 2
   SonstigeThe solvent was evaporated
3. 3
   Sonstigethe crude was partitioned between water and Et2O
4. 4
   TrocknenThe organic phase was dried (Na2SO4)
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe crude was purified by flash chromatography with ethyl acetate-petroleum ether (2-8)

Vorschrift

2,4-Di-methoxy-pyrimidine-5-boronic acid (500 mg, 2.72 mmol) was dissolved in degassed n-PrOH (40 mL) and then 2-bromo-6-methylpyridine (660 mg, 3.8 mmol), Na2CO3 (865 mg, 8.16 mmol), PPh3 (215 mg, 0.8 mmol) and Pd(OAc)2 (50 mg, 0.22 mmol) were added. The suspension was stirred at reflux for 4 hours. The solvent was evaporated and the crude was partitioned between water and Et2O. The organic phase was dried (Na2SO4) and evaporated. The crude was purified by flash chromatography with ethyl acetate-petroleum ether (2-8) to give 300 mg of the title compound (47% yield).

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