Reaktion #40954

Reaktionsgleichung

water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

1-bromo-4-chloro-butane

→

title compound

Ausbeute 98.0%

3-Benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

Ausbeute 98.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   TrocknenThe organic phase was dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated
6. 6
   Sonstigethe crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3)

Vorschrift

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 2.5 g, 7.3 mmol), K2CO3 (1 g, 7.3 mmol) and 1-bromo-4-chloro-butane (2.10 mL, 18 mmol) were suspended in dry DMF (10 mL). After stirring the reaction at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated; the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3) to give the title compound as a white solid (3 g, 98% yield).

Quelle