Reaktion #40951

Reaktionsgleichung

Water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

bromo-chloro-propane

→

title compound

Ausbeute 98.1%

3-Benzoyl-1-(3-chloro-propyl)-5-iodo-1H-pyrimidine-2,4-dione

Ausbeute 98.1%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred at room temperature overnight
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   TrocknenThe organic phase was dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated

Vorschrift

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 3 g, 8.77 mmol) and K2CO3 (1.2 g, 8.77 mmol) were suspended in dry DMF (45 mL) and stirred at room temperature for 1 h. Then, bromo-chloro-propane (2.7 mL, 17.5 mmol) was added dropwise and the mixture stirred at room temperature overnight. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated to give the title compound as a pale yellow oil (3.6 g, 98% yield).

Quelle