Reaktion #40945

Reaktionsgleichung

(2-Cyano-3-ethoxy-acryloyl)-carbamic acid ethyl ester

3,3-diethoxypropylamine

→

title compound

Ausbeute 92.2%

1-(3,3-Diethoxy-propyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile

Ausbeute 92.2%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe residue was purified by flash chromatography with petroleum ether-ethyl acetate (1-1)

Vorschrift

(2-Cyano-3-ethoxy-acryloyl)-carbamic acid ethyl ester (Prep 33, 300 mg, 1.42 mmol) was suspended in water (20 mL); 3,3-diethoxypropylamine (460 μl, 2.84 mmol) was added and the mixture warmed at 80° C. for 10 minutes. The reaction mixture was lyophilized and the residue was purified by flash chromatography with petroleum ether-ethyl acetate (1-1) to give 350 mg of the title compound (91% yield)

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