Reaktion #409290

Reaktionsgleichung

4-piperidone monohydrate hydrochloride

AlCl3

benzene

water

→

off-white solid

Ausbeute 72.0%

4,4-Diphenylpiperidine hydrochloride

Ausbeute 72.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 4 hours
2. 2
   Filtrationfiltered
3. 3
   WaschenThe solid was washed with toluene
4. 4
   Sonstigedried

Vorschrift

A mixture of 4-piperidone monohydrate hydrochloride (15.0 g, 97.6 mmol, 1.00 equiv) and AlCl3 (130 g, 976 mmol, 10.0 equiv) in anhydrous benzene (600 mL) was stirred at reflux for 4 hours. The mixture was cooled to room temperature, poured into ice (300 g) and water (50 mL), and filtered. The solid was washed with toluene and dried to afford 19.2 g (72%) of off-white solid, which was characterized spectroscopically.

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