Reaktion #40929

Reaktionsgleichung

Water

5-methyl-2,4(1H,3H)-pyrimidinedione

K2CO3

1-bromo-4-chloropentane

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title compound

1-(4-chloropentyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 4 hours
2. 2
   Extraktionthe resulting mixture was extracted with dichloromethane
3. 3
   Extraktionextracted with DCM
4. 4
   SonstigeThe organic phases were dried
5. 5
   Einengenconcentrated in vacuo
6. 6
   SonstigeThe crude product was purified by a silica SPE cartridge
7. 7
   Wascheneluting with DCM/MeOH from 98/2 to 95/5

Vorschrift

A mixture of 5-methyl-2,4(1H,3H)-pyrimidinedione (thimine, 500 mg) and K2CO3 (548 g) in dry DMF (15 mL) was stirred for 1 hour at room temperature. 1-bromo-4-chloropentane (0.548 mL) was then added and the mixture was stirred at room temperature for 4 hours. Water was then added and the resulting mixture was extracted with dichloromethane. The aqueous phase was acidified to pH 7 with aqueous 2% HCl solution and extracted with DCM. The organic phases were dried and concentrated in vacuo. The crude product was purified by a silica SPE cartridge eluting with DCM/MeOH from 98/2 to 95/5 to give the title compound (100 mg).

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