Reaktion #409264

Reaktionsgleichung

4-6

[Tert-butoxycarbonyl-(4-oxo-pentyl)-amino]-propionic acid ethyl ester

2-amino-3-formylpyridine

proline

→

4-7

[Tert-butoxycarbonyl-(3-[1,8]naphthyridin-2-yl-propyl)-amino]-propionic acid ethyl ester

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 15 h
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigeevaporation
4. 4
   Sonstigethe residue was chromatographed (silica gel, 1:1 chloroform/ethyl acetate)

Vorschrift

To a solution of 4-6 (12 g, 40 mmol), 2-amino-3-formylpyridine (6.3 g, 52 mmol), proline (4.6 g, 40 mmol) and ethanol (300 mL) was heated at reflux for 15 h. After cooling and evaporation, the residue was chromatographed (silica gel, 1:1 chloroform/ethyl acetate) to give 4-7 as a yellow oil.

Quelle