Reaktion #409110

Reaktionsgleichung

3,4,5-trimethoxybenzenesulfonyl chloride

3-hydroxy-4-methoxyaniline

→

product

1-[(3-Hydroxy-4-methoxyphenyl)aminosulfonyl]-3,4,5-trimethoxybenzene

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe reaction mixture was concentrated
2. 2
   Sonstigethe crude residue was purified by chromatography over silica

Vorschrift

To a solution of 3,4,5-trimethoxybenzenesulfonyl chloride (500 mg, 1.88 nmol) in methanol (10 mL) was added 3-hydroxy-4-methoxyaniline (523 mg, 3.76 mmol) at ambient temperature. After stirring for 1 h, the reaction mixture was concentrated and the crude residue was purified by chromatography over silica to afford 430 mg (62%) of product as fine white needles, m.p. 145-146° C.

Quelle