Reaktion #409108

Reaktionsgleichung

5-bromo-2,3,4-trifluorophenylsulfonyl chloride

2-bromo-3,4,5-trifluorophenylsulfonyl chloride

3-hydroxy-4-methoxyaniline

→

1-Bromo-2,3,4-trifluoro-5-[(3-hydroxy-4-methoxyphenyl)aminosulfonyl]benzene

1-Bromo-4,5,6-trifluoro-2-[(3-hydroxy-4-methoxyphenyl)amino-sulfonyl]benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe two isomeric compounds were separated by column chromatography (silica gel; ethyl acetate:hexanes, 1:4)

Vorschrift

1-Bromo-2,3,4-trifluoro-5-[(3-hydroxy-4-methoxyphenyl)aminosulfonyl]benzene and 1-Bromo-4,5,6-trifluoro-2-[(3-hydroxy-4-methoxyphenyl)amino-sulfonyl]benzene were prepared in a manner similar to that described above, beginning with a mixture of 5-bromo-2,3,4-trifluorophenylsulfonyl chloride (Example B) and 2-bromo-3,4,5-trifluorophenylsulfonyl chloride (Example C) and 3-hydroxy-4-methoxyaniline. The two isomeric compounds were separated by column chromatography (silica gel; ethyl acetate:hexanes, 1:4).

Quelle