Reaktion #40858

Reaktionsgleichung

2-chloro-6-phenyl-5-p-tolylnicotinonitrile

Compound 115

2-chloro-6-phenyl-5-p-tolylnicotinonitrile

morpholine

→

title compound

2-Morpholino-6-phenyl-5-p-tolylnicotinonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents was removed
2. 2
   Sonstigethe residue was purified by MPLC column chromatography (silica gel, 10% ethyl acetate in hexane)

Vorschrift

A solution of 2-chloro-6-phenyl-5-p-tolylnicotinonitrile (Compound 115, 124 mg, 0.4 mmol) and morpholine (36 mg, 0.4 mmol) in DMF (2 ml) was heated at 150° C. for 2 hours. The solvents was removed and the residue was purified by MPLC column chromatography (silica gel, 10% ethyl acetate in hexane) to obtain the title compound as a white solid.

Quelle