Reaktion #40821

ord-f84eb07691ad48848f4d45b22cacaa43

Reaktionsgleichung

O=C([O-])c1ccccn1
pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccn2)n1
Compound 50
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccn2)n1
Ethyl 3-(4-Ethylphenyl)-[2,2′]-bipyridinyl-6-carboxylate
→
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccccn2)cc1
title compound
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccccn2)cc1
Methyl 5-(4-ethylphenyl)-6-(pyridin-2-yl)pyridine-2-carboxylate

Edukte

O=C([O-])c1ccccn1
pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccn2)n1
Compound 50
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccccn2)n1
Ethyl 3-(4-Ethylphenyl)-[2,2′]-bipyridinyl-6-carboxylate

Reagenzien

O=S(=O)(O)O
H2SO4

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(pyridine-2-yl)phenyl)pyridine-2-carboxylate (Compound 50, 16 mg, 0.05 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728014B2uspto-grants-2010_06