Reaktion #40802

ord-44b6bfd75d794d3281b750bfa16d6f38

Reaktionsgleichung

C=CN1CCCC1
Compound 38
C=CN1CCCC1
1-vinylpyrrolidine
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 19
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate
C=CN1CCCC1
1-vinylpyrrolidine
→
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
title compound
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Ethyl 5-Phenyl-6-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylate

Edukte

C=CN1CCCC1
Compound 38
C=CN1CCCC1
1-vinylpyrrolidine
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 19
CCOC(=O)c1nnc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate
C=CN1CCCC1
1-vinylpyrrolidine

Reagenzien

Keine

Lösungsmittel

ClC(Cl)Cl
CHCl3

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

Following General Procedure D, ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate (Compound 19, 1 g, 2.68 mmol) and crude 1-vinylpyrrolidine (Compound 38, 1.4 g) in CHCl3 (20 ml) were reacted to produce the title compound as a yellow oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728014B2uspto-grants-2010_06