Reaktion #40789

Reaktionsgleichung

methyl chloroformate

2-chloro-benzenesulfonamide

triethylamine

→

white solid

(2-Chloro-benzenesulfonyl)-carbamic acid methyl ester

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled with an ice bath
2. 2
   Einengenconcentrated in vacuo
3. 3
   workup.ADDITIONWater was added and de aqueous layer
4. 4
   Waschenwas washed two times with ether
5. 5
   FiltrationThe suspension was filtered
6. 6
   Waschenthe residue was washed with H2O
7. 7
   Sonstigedried in vacuo

Vorschrift

To 25.0 g 2-chloro-benzenesulfonamide was added 75 mL acetonitrile and 45.2 mL (2.5 eq) triethylamine. The mixture was cooled with an ice bath and 15.1 mL methyl chloroformate was slowly added dropwise. The mixture was stirred overnight at room temperature and concentrated in vacuo. Water was added and de aqueous layer was washed two times with ether. Acidification of the aqueous layer with 2 M HCl led to formation of a white precipitate. The suspension was filtered, the residue was washed with H2O and dried in vacuo to yield 19.1 g of a white solid. 1H NMR (400 MHz, DMSO-d6) δ 3.58 (s, 3H), 7.52-7.61 (m, 1H), 7.62-7.72 (m, 2H), 8.10 (dd, J=8 and 1.5 Hz, 1H), 12.42 (br s, 1H).

Quelle