Reaktion #40782

Reaktionsgleichung

C-(4-Aminomethyl-1-benzyl-piperidin-4-yl)-methylamine

MeOH

H2O2

NaClO

→

yellow oil

Ausbeute 90.3%

8-Benzyl-2,3,8-triaza-spiro[4.5]dec-2-ene

Ausbeute 90.3%

Lösungsmittel

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted 2 times with DCM
2. 2
   Trocknenthe combined organic layers were dried over Na2SO4
3. 3
   Filtrationfiltrated
4. 4
   Einengenconcentrated

Vorschrift

2.48 g of C-(4-Aminomethyl-1-benzyl-piperidin-4-yl)-methylamine was suspended in 40 mL H2O and 10 mL MeOH and cooled with an ice bath. Simultaneously, 6.7 mL 30% H2O2 (6 equiv.) and 15.2 mL 10% NaClO (2.4 equiv.) were added dropwise. The mixture was stirred at room temperature for 1 hour. The mixture was extracted 2 times with DCM, the combined organic layers were dried over Na2SO4, filtrated and concentrated to yield 2.20 g of a yellow oil which was used without further purification in the subsequent step.

Quelle