Reaktion #40770

Reaktionsgleichung

p-chloroacetophenone

dimethylamine hydrochloride

paraformaldehyde

HCl

→

product

Ausbeute 112.0%

1-(4-Chloro-phenyl)-3-dimethylamino-propan-1-one hydrochloride

Ausbeute 112.0%

Lösungsmittel

acetone

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 5 h
2. 2
   Temperaturwas cooled further to 20° C
3. 3
   FiltrationThe precipitate was filtered
4. 4
   Waschenwashed with acetone and PA, and air
5. 5
   Sonstigedried

Vorschrift

To EtOH (80 mL), p-chloroacetophenone (77.3 g, 0.50 mol), dimethylamine hydrochloride (52.7 g, 0.65 mol), paraformaldehyde (19.8 g, 0.66 mol) and concentrated aqueous HCl (1 mL) were added and the mixture was refluxed for 5 h. The mixture was cooled to 40° C., acetone (400 mL) was added, and under stirring the mixture was cooled further to 20° C. The precipitate was filtered, washed with acetone and PA, and air dried to obtain 69.5 g of product which was used without further purification in the subsequent step.

Quelle