Reaktion #40768

Reaktionsgleichung

HCl

acetophenone

paraformaldehyde

dimethylamine hydrochloride

→

white crystalline material

3-Dimethylamino-1-phenyl-propan-1-one hydrochloride

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 3 h
2. 2
   Filtrationthe precipitate was filtered
3. 3
   Waschenwashed with acetone
4. 4
   Sonstigedried in vacuo

Vorschrift

To a solution of 0.5 mL concentrated aqueous HCl in 40 mL EtOH, acetophenone (30.0 g), paraformaldehyde (10.0 g) and dimethylamine hydrochloride (26.5 g) were added and the mixture was refluxed for 3 h. The mixture was cooled to room temperature, and the precipitate was filtered, washed with acetone and dried in vacuo to obtain 37.2 g of white crystalline material. 1H NMR (200 MHz, DMSO-d6) δ 2.84 (s, 6H), 3.38-3.55 (m, 2H), 3.57-3.74 (m, 2H), 7.48-7.73 (m, 3H), 7.97-8.10 (m, 2H).

Quelle