Reaktion #40743

Reaktionsgleichung

THF

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester

THF

lithium hydroxide

→

title compound

5-chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid precipitate is collected
2. 2
   Waschenwashed with water and ether
3. 3
   Sonstigedried under high vacuum

Vorschrift

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester (62 g, 35 mmol) is dissolved in. THF (10 ml), and aqueous lithium hydroxide solution (2.0 N, 6.35 ml, 2.0 eq.) is added. The mixture is heated at 50° C. overnight. THF is stripped off under reduced pressure, and the residue is diluted with water (10 ml) and basified to pH=4=5. The solid precipitate is collected, washed with water and ether, and dried under high vacuum to give the title compound. LCMS 301 (M+1).

Quelle