Reaktion #4074

ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a

Reaktionsgleichung

COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
(S)-2-(6-methoxy-2-naphthyl)propionic acid
Cl
hydrogen chloride
→
COc1ccc2cc([C@H](C)C(=O)OCC(C)C)ccc2c1
isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

Edukte

COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
(S)-2-(6-methoxy-2-naphthyl)propionic acid
Cl
hydrogen chloride

Reagenzien

Keine

Lösungsmittel

CC(C)CO
isobutyl alcohol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISTILLATIONthe excess alcohol is distilled off in vacuo
  2. 2
    Sonstigethe residue is purified by chromatography

Vorschrift

A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04723033uspto-grants-1988_02