Reaktion #40710

Reaktionsgleichung

4-morpholinoacetophenone

N,N-dimethylformamide dimethyl acetal

hydrazine hydrate

→

title compound

4-[4-(1H-Pyrazol-3-yl)phenyl]morpholine

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 7 hours
3. 3
   Temperaturagain heated
4. 4
   Temperaturunder reflux for about 6 hours
5. 5
   SonstigeThe solid formed
6. 6
   Temperaturon cooling the mixture
7. 7
   Filtrationwas filtered off with suction
8. 8
   Waschenthoroughly washed with methanol

Vorschrift

A mixture of 2.05 g of 4-morpholinoacetophenone (10 mmol) and N,N-dimethylformamide dimethyl acetal was heated under reflux for 7 hours. The mixture was then mixed with 30 ml of methanol and, after addition of 0.57 ml of hydrazine hydrate, again heated under reflux for about 6 hours. The solid formed on cooling the mixture was filtered off with suction and thoroughly washed with methanol, resulting in 3.8 g of the title compound.

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