Reaktion #4070

Reaktionsgleichung

methyl bromo-phenylacetate

methyl ammonium chloride

sodium bicarbonate

water

→

title compound

Ausbeute 71.2%

Methyl Methyamino-phenylacetate

Ausbeute 71.2%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto refluxed
2. 2
   Temperaturrefluxed for about 18 hours
3. 3
   TemperaturThe mixture was then cooled
4. 4
   Waschenwashed three times with water
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Einengenconcentrated by vacuum evaporation

Vorschrift

In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.

Quelle