Reaktion #40690

ord-b06412e6adab493bad4027094337a0c0

Reaktionsgleichung

CSC[C@@H](CO)NC(=O)OC(C)(C)C
t-butyl (1R)-2-hydroxy-1-[(methylsulfanyl)methyl]ethylcarbamate
Cc1cccc(O)c1
m-cresol
Oc1cccc(F)c1
3-fluorophenol
CSC[C@@H](COc1cccc(F)c1)NC(=O)OC(C)(C)C
title compound
CSC[C@@H](COc1cccc(F)c1)NC(=O)OC(C)(C)C
t-butyl (1R)-2-(3-fluorophenoxy)-1-[(methylsulfanyl)methyl]ethylcarbamate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By the operation similar to that in Step 2 of Example 15 except that t-butyl (1R)-2-hydroxy-1-[(methylsulfanyl)methyl]ethylcarbamate (1 g) obtained in Step 1 was used as a starting material and m-cresol was changed to 3-fluorophenol, the title compound (300 mg) was obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728005B2uspto-grants-2010_06