Reaktion #40685

Reaktionsgleichung

5-aminoisoquinoline

phenyl chloroformate

pyridine

tetrahydrofuran

→

title compound

phenyl isoquinolin-5-ylcarbamate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and saturated aqueous sodium hydrogen carbonate
2. 2
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
3. 3
   Sonstigethe solvent was evaporated
4. 4
   workup.ADDITIONDiethyl ether was added to the residue
5. 5
   Filtrationthe precipitate was collected by filtration

Vorschrift

To 5-aminoisoquinoline (2.7 g) were added phenyl chloroformate (2.85 ml), pyridine (2.0 ml) and tetrahydrofuran (50 ml), and the mixture was stirred for 3 hrs. The reaction mixture was diluted with dichloromethane, and washed with water and saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated. Diethyl ether was added to the residue, and the precipitate was collected by filtration to give the title compound (3 g).

Quelle