Reaktion #40677

Reaktionsgleichung

20f

2-(1′-neopentylspiro[indoline-3,4′-piperidine]-1-yl)aniline

benzoylisothiocyanate

→

N-(2-(1′-neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenylcarbamothioyl)benzamide

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was concentrated
2. 2
   Sonstigethe residue was purified by flash chromatography (silica gel, 0-10% MeOH/DCM)
3. 3
   Sonstigeto give 20 g

Vorschrift

A mixture of 20f (118 mg, 0.33 mmol) and benzoylisothiocyanate (63 μL, 0.47 mmol) in DCM (3 mL) was stirred at rt for 3 h. The reaction was concentrated and the residue was purified by flash chromatography (silica gel, 0-10% MeOH/DCM) to give 20 g, as yellow solid (156 mg). LC-MS m/z 513.06 [M+H]+.

Quelle