Reaktion #40669

Reaktionsgleichung

2f

1-benzoyl-3-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea

NaOH

→

1-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated under reduced pressure and co-evaporated with toluene
2. 2
   Sonstigeto afford 2 g (35 mg, 80%)

Vorschrift

To a solution of 2f (60 mg, 0.149 mmol) in MeOH was added 1N NaOH (0.2 mL, 0.2 mmol). The reaction mixture was stirred at 50° C. for 2 h. The solvent was evaporated under reduced pressure and co-evaporated with toluene to afford 2 g (35 mg, 80%). MS (ES) m/z 298 [M+H]30 .

Quelle