Reaktion #40666

Reaktionsgleichung

2c

3,3-dimethylindoline

1-fluoro-2-nitrobenzene

→

2d

Ausbeute 95.0%

3,3-dimethyl-1-(2-nitrophenyl)indoline

Ausbeute 95.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 1N HCl
2. 2
   Trocknendried over Na2SO4
3. 3
   SonstigeThe solvent was evaporated under reduced pressure
4. 4
   Sonstigepurified by column chromatography
5. 5
   Sonstigeover 30 min
6. 6
   Waschenas eluting solvent

Vorschrift

To 2c (317 mg, 2.12 mmol) was added 1-fluoro-2-nitrobenzene (200 mg, 1.42 mmol). The reaction mixture was stirred at 175° C. for 8 h. The reaction mixture was diluted with CH2Cl2 and washed with 1N HCl and dried over Na2SO4. The solvent was evaporated under reduced pressure and purified by column chromatography using 0 to 10% EtOAc in hexane over 30 min as eluting solvent to afford 2d (360 mg, 95%) as an oil. MS (ES) m/z 269 [M+H]+.

Quelle