Reaktion #40583

Reaktionsgleichung

calcium carbonate

benzyltrimethylammonium dichloroiodate

5-amino-2-chloropyridine

→

expected product

Ausbeute 39.1%

3-Amino-6-chloro-2-iodopyridine

Ausbeute 39.1%

Lösungsmittel

methanol

dichloro-methane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   Sonstigeto remove the mineral salts
3. 3
   workup.ADDITIONThe filtrate is diluted with water
4. 4
   Extraktionextracted with DCM
5. 5
   SonstigeThe organic phase obtained
6. 6
   Waschenis washed with sodium chloride solution
7. 7
   Trocknenwith saturated sodium thiosulfate solution, dried over magnesium sulfate
8. 8
   Einengenconcentrated under reduced pressure
9. 9
   SonstigeAn oil is obtained
10. 10
    Sonstigewhich is purified by chromatography on silica gel
11. 11
    Wascheneluting with a cyclohexane/ethyl acetate mixture (80/20

Vorschrift

23.2 g (180.5 mM) of 5-amino-2-chloropyridine are mixed in 70 ml of dichloro-methane (DCM) and 180 ml of methanol, and 21.6 g (216 mM) of calcium carbonate and 75.3 g (226 mM) of benzyltrimethylammonium dichloroiodate are added. The reaction mixture is stirred at room temperature for 16 hours, and then filtered to remove the mineral salts. The filtrate is diluted with water and extracted with DCM. The organic phase obtained is washed with sodium chloride solution, and then with saturated sodium thiosulfate solution, dried over magnesium sulfate and concentrated under reduced pressure. An oil is obtained, which is purified by chromatography on silica gel, eluting with a cyclohexane/ethyl acetate mixture (80/20 and then 70/30; v/v). 13.9 g of the expected product are thus obtained in the form of an orange-colored solid (yield=30%).

Quelle