Reaktion #40576

Reaktionsgleichung

4-Chlorophenylacetic acid

hydrogen chloride methanol

→

methyl 2-(4-chlorophenyl)acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated under reflex for 14 hours
2. 2
   SonstigeThe solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   Extraktionfollowed by extraction with ethyl acetate
5. 5
   TrocknenThe organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure

Vorschrift

4-Chlorophenylacetic acid (5.0 g) was dissolved in 10% hydrogen chloride-methanol solution (50 ml) and heated under reflex for 14 hours. The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure to provide methyl 2-(4-chlorophenyl)acetate (5.35 g) as a colorless, oily substance.

Quelle