Reaktion #40546

ord-0d9dbd0ceb884aa9952e31fab8bb9478

Reaktionsgleichung

CCNc1nccc(C(C)=O)n1
1-(2-ethylaminopyrimidin-4-yl)ethanone
CCOC(=O)C(=O)C(=O)OCC
diethyl ketomalonate
→
CCNc1nccc(C(=O)CC(O)(C(=O)OCC)C(=O)OCC)n1
Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxy-malonate

Edukte

CCNc1nccc(C(C)=O)n1
1-(2-ethylaminopyrimidin-4-yl)ethanone
CCOC(=O)C(=O)C(=O)OCC
diethyl ketomalonate

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
110°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2)

Vorschrift

A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727989B2uspto-grants-2010_06