Reaktion #40499

Reaktionsgleichung

4-methyl-9H-β-carboline

NCS

sodium bicarbonate

→

6-chloro-4-methyl-9H-β-carboline

Ausbeute 93.7%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was stirred for 5 hr
2. 2
   Extraktionthe reaction mixture was extracted twice with EtOAc (100 ml)
3. 3
   WaschenThe combined organic layers were washed with brine
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated

Vorschrift

4-methyl-9H-β-carboline (97 mg, 0.532 mmol) was dissolved in HCl (1N, 4 ml) and stirred at RT. NCS (85 mg, 0.637 mmol) was added thereto and the reaction mixture was stirred for 5 hr. Saturated sodium bicarbonate solution (20 ml) was added thereto and the reaction mixture was extracted twice with EtOAc (100 ml). The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give 6-chloro-4-methyl-9H-β-carboline (108 mg) as an oil.

Quelle