Reaktion #40490

Reaktionsgleichung

2-benzoyl-6-chloro-1,2,3,9-tetrahydro-β-carbolin-4-one

hydrazine

→

4-amino-6-chloro β-carboline

Ausbeute 30.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to room temperature
2. 2
   SonstigeThe precipitated yellow solids were removed by filtration
3. 3
   Waschenwashed with water, 2×5 ml

Vorschrift

Crude 2-benzoyl-6-chloro-1,2,3,9-tetrahydro-β-carbolin-4-one (4 g) was dissolved in 30 ml of anhydrous hydrazine and stirred at reflux (130° C. oil bath) under N2 for 6 hours, after which the reaction mixture was allowed to cool to room temperature and sit overnight. The precipitated yellow solids were removed by filtration and washed with water, 2×5 ml, to yield 785 mg (30%) of 4-amino-6-chloro β-carboline as an off white solid. Additional water was added to the combined filtrates until no further precipitation occurred. These solids were also removed by filtration to give 1.056 g (39%) of 4-amino-6-chloro β-carboline as yellow solids, (69% total yield).

Quelle