Reaktion #40476

Reaktionsgleichung

di-HCl

2-methyl nicotinic acid

6-chloro-7-fluoro-9H-β-carbolin-8-ylamine

EDCI

→

N-(6-chloro-7-fluoro-9H-β-carbolin-8-yl)-2-methyl-nicotinamide

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe pyridine was removed under reduced pressure
2. 2
   Sonstigethe resulting dark oil was triturated with saturated aqueous NaHCO3
3. 3
   SonstigeThe precipitate which formed
4. 4
   Filtrationwas filtered
5. 5
   Waschenwashed with MeOH
6. 6
   workup.ADDITIONThe material was treated with 2M HCl in Et2O
7. 7
   Sonstigeto yield a gray solid

Vorschrift

A solution of 6-chloro-7-fluoro-9H-β-carbolin-8-ylamine (100 mg, 0.424 mmol) in pyridine (2.5 ml) was stirred at RT. 2-methyl nicotinic acid (70 mg, 0.509 mmol) was added, followed by EDCI (130 mg, 0.678 mmol). The suspension was stirred at 100° C. for a day. The pyridine was removed under reduced pressure and the resulting dark oil was triturated with saturated aqueous NaHCO3. The precipitate which formed was filtered and washed with MeOH. The material was treated with 2M HCl in Et2O to yield a gray solid, the di-HCl salt N-(6-chloro-7-fluoro-9H-β-carbolin-8-yl)-2-methyl-nicotinamide (110 mg).

Quelle