Reaktion #40474

ord-970f2d8f6a31410c9eb7931d5d8ac635

Reaktionsgleichung

Nc1c(OCC2CC2)c(Cl)cc2c1[nH]c1cnccc12
6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine
Cc1ncccc1C(=O)O
2-methylnicotinic acid
→
Cc1ncccc1C(=O)Nc1c(OCC2CC2)c(Cl)cc2c1[nH]c1cnccc12
desired compound
Ausbeute 40.0%
Cc1ncccc1C(=O)Nc1c(OCC2CC2)c(Cl)cc2c1[nH]c1cnccc12
N-(6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-yl)-2-methyl-nicotinamide
Ausbeute 40.0%

Edukte

Nc1c(OCC2CC2)c(Cl)cc2c1[nH]c1cnccc12
6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine
Cc1ncccc1C(=O)O
2-methylnicotinic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The desired compound was prepared according to Method A from 6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine and 2-methylnicotinic acid in a 40-60% yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727985B2uspto-grants-2010_06