Reaktion #40473

Reaktionsgleichung

6-chloro-7-cyclopropylmethoxy-8-nitro-9H-β-carboline

hydrogen

NaHCO3

→

6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine

Ausbeute 80.1%

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationUpon filtration
2. 2
   Sonstigethrough a pad of celite and evaporation of the methanol
3. 3
   Sonstigea dark brown solid was obtained
4. 4
   SonstigeThe light brown solid that precipitated out
5. 5
   Filtrationwas collected by filtration
6. 6
   Sonstigedried thoroughly in vacuo

Vorschrift

6-chloro-7-cyclopropylmethoxy-8-nitro-9H-β-carboline (510 mg, 1.61 mmol) was suspended in 12 ml of methanol and 100 mg of Pd/C(10%) was added. The flask was fitted with a balloon of hydrogen and the reaction mixture was stirred overnight at RT. Upon filtration through a pad of celite and evaporation of the methanol, a dark brown solid was obtained. This residue was suspended in methanol (10 ml) and added, with vigorous stirring, to a solution of saturated NaHCO3 (100 ml). The light brown solid that precipitated out was collected by filtration and dried thoroughly in vacuo to give the desired 6-chloro-7-cyclopropylmethoxy-9H-β-carbolin-8-ylamine (371 mgs, 80% yield).

Quelle