Reaktion #40465

ord-893383a6f6244cf79604ae38fdab3519

Reaktionsgleichung

Nc1cc(Cl)cc2c1[nH]c1cnccc12
6-chloro-9H-β-carboline-8-ylamine
CN1C(=O)CC(C(=O)O)C1(C)C
1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid
→
CN1C(=O)CC(C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)C1(C)C
desired compound
Ausbeute 68.0%
CN1C(=O)CC(C(=O)Nc2cc(Cl)cc3c2[nH]c2cnccc23)C1(C)C
1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-β-carbolin-8-yl)-amide
Ausbeute 68.0%

Edukte

Nc1cc(Cl)cc2c1[nH]c1cnccc12
6-chloro-9H-β-carboline-8-ylamine
CN1C(=O)CC(C(=O)O)C1(C)C
1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The desired compound was prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid in 68% yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727985B2uspto-grants-2010_06