Reaktion #40462

Reaktionsgleichung

DMSO

6-chloro-7-fluoro-8-nitro-9H-β-carboline

1-methylpiperazine

DIEA

→

6-chloro-7-(4-methyl-piperazin-1-yl)-8-nitro-9H-β-carboline

Ausbeute 91.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigean orange solid precipitated out
2. 2
   FiltrationThe solid was filtered
3. 3
   Waschenwashed
4. 4
   Sonstigedried

Vorschrift

To a DMSO solution (4 ml) of 200 mg (0.755 mmol) of 6-chloro-7-fluoro-8-nitro-9H-β-carboline was added 1-methylpiperazine (226 mg, 2.26 mmol) and DIEA (400 mg, 3.09 mmol) via a syringe. The reaction was allowed to stir at RT overnight. Upon addition of water, an orange solid precipitated out. The solid was filtered, washed and dried to give 236 mg (91% yield) of the desired 6-chloro-7-(4-methyl-piperazin-1-yl)-8-nitro-9H-β-carboline.

Quelle