Reaktion #40428

Reaktionsgleichung

citraconic anhydride

2-amino-5-bromopyridine

→

solid

Ausbeute 71.0%

N-(5-bromopyridin-2-yl)-methylmaleimide

Ausbeute 71.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux overnight
3. 3
   TemperaturThe solution was cooled down
4. 4
   Filtrationfiltered
5. 5
   EinengenThe filtrate was concentrated in vacuo

Vorschrift

A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).

Quelle