Reaktion #40373

Reaktionsgleichung

ammonium chloride

methylmagnesium bromide

1-(4-ethylphenyl)propan-2-one

→

1-(4-ethylphenyl)-2-methylpropan-2-ol

Lösungsmittel

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile being cooled with an ice bath in such a way that the temperature
2. 2
   Sonstigedoes not exceed 30° C
3. 3
   workup.ADDITIONAfter the addition
4. 4
   Temperaturthe reaction mixture is refluxed for 1.5 hours
5. 5
   SonstigeAfter the removal of the organic phase
6. 6
   Extraktionthe aqueous phase is extracted with diethyl ether
7. 7
   WaschenThe combined ether phases are washed with water
8. 8
   Trocknendried with sodium sulfate
9. 9
   Sonstigeevaporated down
10. 10
    SonstigeThe oil thus obtained
11. 11
    Sonstigeis further reacted directly

Vorschrift

14.8 g (90 mmol) of 1-(4-ethylphenyl)propan-2-one dissolved in diethyl ether is added dropwise to 39 mL of a 3 molar solution of methylmagnesium bromide in diethyl ether while being cooled with an ice bath in such a way that the temperature does not exceed 30° C. After the addition has ended, the reaction mixture is refluxed for 1.5 hours and then hydrolyzed with 10% ammonium chloride solution. After the removal of the organic phase, the aqueous phase is extracted with diethyl ether. The combined ether phases are washed with water, dried with sodium sulfate, and evaporated down. The oil thus obtained is further reacted directly. Yield: 15.5 g (90%).

Quelle